Askarani et al., in 2020, used molecular hybridization and bioisosteric replacement strategies to synthesize 1,2,3-triazole-dimethylamino acryloyl-chromenones as MTDLs possessing anti-AChE/BuChE, anti-Aβ aggregation, neuroprotective, and metal-chelating properties beneficial in the treatment of AD. This evidence concerns the gene ACHE and Alzheimer disease.