Indeed, compared to previous studies that were performed on HSPB5 knock-out mice in which HSPB5 was deleted before the induction of lung fibrosis, our study demonstrates the anti-fibrotic role of HSPB5 inhibition with NCI-41356 administered at the later stages of bleomycin-induced fibrosis (D9-D12) when fibrosis is already initiated and progressive. The gene discussed is CRYAB; the disease is fibrosis.