ORAI1 and cancer: With the determination of the roles of Orai and STIM in cancer, studies involving the pharmacological inhibition of SOCE or downregulation of STIM1 have been revealed to enhance apoptosis induced by cisplatin in non-small cell lung cancer cells, and Orai1/STIM1 are associated with a protective antiapoptotic role in ovary carcinoma cells [70].