AKT1 and malignant colon neoplasm: In another report, withaferin A inhibited the Notch signaling pathway and downregulated Akt/NF-ĸB/Bcl-2 and the expression of rapamycin signaling elements PS6K and p4E-BP1 in HCT-116, SW-480, and SW-620 colon cancer cells [126].