CDK4 and pancreatic neoplasm: In the treatment of pancreatic cancer, withaferin A encapsulated with a methoxy poly(ethylene glycol) (mPEG) conjugated poly(D,L-lactide-co-glycolide) (PLGA), exhibited strong anticancer properties as compared to the free form, and it also allowed strong bonding to heat-shock proteins, reducing the expression of Akt and CDK4 proteins and causing apoptosis in cancer cells [249].