Nevertheless, psoriasis is characterized by effector T cell activation, dysregulated inflammatory cytokine expression—TNF-α, IL-17A/F, IL-22, IL-23, or GM-CFS—and angiogenic growth factors that flare up throughout the pathway, including hypoxia inducible factor-1α (HIF-1α) and vascular endothelial growth factor (VEGF) [194,195]. The gene discussed is VEGFA; the disease is psoriasis.