CDH2 and cancer: Besides showing morphological changes, cancer cells undergoing EMT also exhibit molecular alterations as demonstrated by the decreased expression of epithelial markers (for example, E-cadherin, ZO-1, and occludin) and increased expression of mesenchymal markers (for example, N-cadherin, vimentin, fibronectin, and fibroblast-specific protein) [96,97,98].