However, miR-17-5p downregulation by an miR-17-5p antagomir significantly reduces the severity of atherosclerosis by reducing the production of inflammatory cytokines, upregulating ATP-binding cassette transporterA1 (ABCA1), reducing lipid accumulation, and activating the PPAR-γ/liver X receptor (LXR) α signaling pathway [99]. The gene discussed is ABCA1; the disease is atherosclerosis.