In a murine model of atherosclerosis, the histone methyltransferase enhancer of zeste homolog 2 (EZH-2), which trimethylates H3K27, was found to aggravate atherosclerosis by suppressing macrophage cholesterol efflux via ABCA-1 (ATP-binding cassette transporter) and accelerating foam cell development [68]. Here, ABCA4 is linked to atherosclerosis.