In another report with in-depth immune checkpoints phenotyping of BM T cells in MM using mass cytometry-based single-cell analysis, Wang et al. confirmed higher expression of these conventional immune checkpoints in T cells and ligands in myeloma cells from MM patients compared with healthy donors (HDs), as well as several newly identified immune checkpoints including LAG3, Tim-3, and TIGIT [175]. Here, LAG3 is linked to Miyoshi myopathy.