These cells were characterized by expressing inflammatory cytokines and chemokines, including several MSC regulators reported previously, such as IL6, CXCL8, CXCL2, PTGS2 and VEGFA, proteins involving in the tumor necrosis factor (TNF) pathway and CCL2, which has been shown to support myeloma cell migration via interacting with CCR2 [220–222]. This evidence concerns the gene TNF and plasma cell myeloma.