Notably, a recent scRNA-seq study refined the molecular features of T cell by comparing MM patients with different bortezomib treatment responses [140], and the authors found that dysfunctional T cells expressing exhausting genes (PD-1, TIGIT, TIM3, CD244, LAG3, CTLA4 and TOX) were enriched in SORs compared to the ORs patients. Here, CTLA4 is linked to Miyoshi myopathy.