Significant upregulation of CD8T cells, and particularly, effector memory CD8T cells (KLRG1+CD8T cells), capable of killing tumor cells in a granzyme B dependent manner [64], in the tbLN and spleen with significant upregulation of IFNγ and IL10 in the tbLN was noted mice in mice administered anti-CTLA4 to the tbLN. Here, CTLA4 is linked to neoplasm.