In detail, cyclic adenosine monophosphate (cAMP) response element-binding protein 1 (CREB1), mediated by nuclear factor erythroid 2-related factor 2 (NRF2), was reported to be essential for the maintenance of GSH dynamics in MSCs; thereby, the CREB1-NRF2 signaling pathway potentiates the function of MSCs, which was shown to increase their therapeutic potential in a humanized mouse model of graft-versus-host disease [37]. The gene discussed is NFE2L2; the disease is graft versus host disease.