Increased AQP4 expression has also been observed in sclerotic hippocampi from patients with TLE, the neuropil of patients with focal cortical dysplasia, and some SUDEP patient cortical astrocytes of the current study, albeit to a lesser extent compared to Alpers’ syndrome patient astrocytes [28, 30, 58]. Here, AQP4 is linked to cerebral cortical dysplasia.