Given the abnormal microglial activation in Csf1r+/− mice and the effective microglial inhibition by minocycline, we then sought to determine whether inhibiting microglial activation by minocycline could reverse the behavioral and pathological deficits displayed in the Csf1r+/− mouse model of ALSP. Here, CSF1R is linked to Hereditary diffuse leukoencephalopathy with axonal spheroids and pigmented glia.