Moreover, in some cases, such as the syngeneic mouse model of breast cancer, epithelial CTCs (defined by high levels of Epcam, E-Cadherin, and Grhl2 expression) have the strongest metastatic ability as compared to the pool of mesenchymal CTCs (low EpCAM, E-cadherin expression, high levels of Vimentin, and EMT-TFs expression) [147]. Here, EPCAM is linked to breast cancer.