If not accompanied by the latter, if associated with fever or increased inflammatory markers (CRP > 6, ESR > 20), plus non-articular bone pain and/or general symptoms (asthenia, adynamia or weight loss), neutrophils < 2,000 or platelets < 300,000, a bone marrow aspirate should be performed to rule out ALL as the cause of the symptoms [11]. The gene discussed is CRP; the disease is acute lymphoblastic leukemia.