We found that the serum TSP-2 level was independently associated with development of early DKD [OR 2.26 (95% CI 1.63–3.14), p < 0.001], together with age [OR 1.06 (95% CI 1.03–1.09), p < 0.001], T2DM duration [OR 1.00 (95% CI 1.00–1.01), p = 0.008], and baseline BMI [OR 1.09 (95% CI 1.02–1.17), p = 0.015]. This evidence concerns the gene THBS2 and type 2 diabetes mellitus.