As expected, HK010 induced a PD-L1 expression-dependent increase in NFκB signaling activity in the positive tumor cell lines, whereas there was no significant change in the PD-L1-negative cell lines, which demonstrated that the 4-1BB signal-stimulating activity of HK010 correlated with the PD-L1 expression level (Fig. 4B). Here, NFKB1 is linked to neoplasm.