Next, the in vivo capacity of HK010 to target T cells to tumor cells was assessed by histopathology for MC38/hPD-L1 tumors, as shown in Fig. 5E. HE staining indicated that HK010 could induce lymphocytes to infiltrate into tumor tissue and resulted in tumor apoptosis and necrosis (Fig. 6B). This evidence concerns the gene CD274 and neoplasm.