Moreover, mIHC results confirmed that HK010 increased the number and percentage of TILs, including CD4+ and CD8+ T cells and NK cells, in the tumor tissue compared with the saline control and anti-PD-L1 mAb (p < 0.001), thereby rescuing the exhausted TILs and exerting potent antitumor immunity in vivo (Fig. 6C, D). This evidence concerns the gene CD4 and neoplasm.