MT1M is also highly involved in cancer, for example, in esophageal squamous cell carcinoma (ESCC) the MT1M expression levels were found to be downregulated, and after its upregulation was induced, MT1M was found to inhibit esophageal cancer cell carcinogenesis through inhibition of epithelial-mesenchymal transition and SOD1/PI3K axis [30]. This evidence concerns the gene SOD1 and esophageal cancer.