It should be noted that the expression levels of LY6E, IFITM1, GADD45A, and MT1M were downregulated in HCC, therefore, except for the expressions of GADD45A and SPP1, which could promote the immune response profile in HCC, the other three appeared to negatively regulate the immune profile of the tumor. The gene discussed is LY6E; the disease is hepatocellular carcinoma.