In another study, it was also mentioned that MT1M was frequently downregulated in HCC, which might be associated with methylation of the promoter region, and upregulation of miR-545-3p, and lead to downregulation of MT1M, which in turn regulates the proliferation, invasion, and migration of hepatocellular carcinoma cells [33, 34]. Here, MT1M is linked to hepatocellular carcinoma.