Accumulating evidence suggests that patients with neurodevelopmental disorders share inherent features of dysregulated homeostasis systems, including the hypothalamic‒pituitary‒adrenal (HPA)-axis, leptin-ghrelin system, insulin resistance, dysbiosis, endocrine and autonomic dysfunctions, and the inflammatory response, which ultimately results in excess adiposity and dysmetabolism [45]. This evidence concerns the gene INS and neurodevelopmental disorder.