WEE1 and obesity due to melanocortin 4 receptor deficiency: The MAPK signaling pathway can phosphorylate a wide range of substrates, including a wide range of nuclear transcription factors and protein kinases, thereby controlling the transcription of related genes; it takes part in several physiological processes, such as cell growth, development, and functional synchronization among cells; it is crucial for adipocyte differentiation, which in turn affects obesity [56].