For example, the PEBP1/15-LO1 complex, which mediates the onset of ferroptosis, is elevated in patients with asthma, which induces airway redox imbalance, thereby causing T2 inflammation and asthma exacerbation [14]; MIR-335-5P targets and regulates ATG5, which reduces the onset of autophagy in the airways of patients with asthma, attenuating an inflammatory response [61]; estrogen receptor 2 transcriptionally suppresses the expression of miRNA-423, which increases the expression level of PINK1 in asthma and mitophagy mediated via PINK1, leading to the worsening of asthma [62]. This evidence concerns the gene ESR2 and asthma.