ACE and aortic valve insufficiency: ACE = angiotensin converting enzyme; AI = aortic valve insufficiency; Ao Asc = aorta ascendens; ARB = angiotensin receptor blocker; BBB = bundle branch block; BMI = body mass index; BP = blood pressure; BSA = body surface area; CMP = cardiomyopathy; LA = left atrium; LP/P: likely pathogenic or pathogenic; LVED = left ventricular end diastole; LVEF = left ventricular ejection fraction; LVES = left ventricular end systole; LVH = left ventricular hypertrophy SoV-Ao = sinuses of valsalva; STJ = sinotubular junction