GPVs which are associated with both ovarian and breast cancer include BRCA1, BRCA2, RAD51C, RAD51D and PALB2. Meanwhile, GPVs associated with ovarian cancer but not associated with breast cancer include those found in LS (MLH1, MSH2, MSH6), and BRIP1 [34]. This evidence concerns the gene MSH2 and ovarian carcinoma.