BRCA1 and Hereditary breast and ovarian cancer syndrome: Testing criteria for inherited breast and ovarian cancer (BRCA1, BRCA2, PALB2, ATM, CHEK2, RAD51C and RAD51D truncating variants) are outlined in the NHS England National Genomic Test Directory which is updated twice per year (available at https://www.england.nhs.uk/publication/national-genomic-test-directories/) [16].