SV burden increased markedly in TP53–/– HGOs between early and late time points (median change of 148%), exceeding by over threefold the change in SV burden (45%) between endoscopies in patients with Barrett’s oesophagus harbouring biallelic TP53 inactivation and who subsequently progressed to oesophageal adenocarcinoma (average 2.2 years, range 0.65–6.16 years)16. The gene discussed is TP53; the disease is esophageal adenocarcinoma.