SV burden increased markedly in TP53–/– HGOs between early and late time points (median change of 148%), exceeding by over threefold the change in SV burden (45%) between endoscopies in patients with Barrett’s oesophagus harbouring biallelic TP53 inactivation and who subsequently progressed to oesophageal adenocarcinoma (average 2.2 years, range 0.65–6.16 years)16. Here, TP53 is linked to Barrett esophagus.