The SVM group separation of APOE ε4 carriers and APOE ε4 noncarriers using 10-fold cross-validation revealed an AUC of 0.98 (ACC = 0.89, SEN = 0.75, and SPE = 0.97) in AD groups, an AUC of 0.91 (ACC = 0.80, SEN = 0.80, and SPE = 0.81) in MCI groups, and an AUC of 0.86 (ACC = 0.78, SEN = 0.88, and SPE = 0.68) in NA groups (Fig. 8a). The gene discussed is APOE; the disease is Alzheimer disease.