RUNX2 and human papilloma virus infection: At Y20, the top pathways associated with recent marijuana use are related to dopamine synapses, diseases of signal transduction, transcription, human papillomavirus infection, and oxytocin signaling; the top pathways associated with cumulative use include diseases of signal transduction, transcription regulation by RUNX2, WNT signaling, human papillomavirus infection, and oxytocin signaling.