At Y20, the top pathways associated with recent marijuana use are related to dopamine synapses, diseases of signal transduction, transcription, human papillomavirus infection, and oxytocin signaling; the top pathways associated with cumulative use include diseases of signal transduction, transcription regulation by RUNX2, WNT signaling, human papillomavirus infection, and oxytocin signaling. This evidence concerns the gene OXT and human papilloma virus infection.