Neisseria gonorrhoeae, the major cause of meningitis and septicemia, Pseudomonas aeruginosa, which is an opportunistic pathogen and the cause of cystic fibrosis and sepsis, and Staphylococcus aureus can stimulate the acid SMase (aSMase) of epithelial cells and fibroblasts, facilitating invasion through a sphingomyelin-decreased and ceramide-enriched platform97–99 and evading the innate immune defense system100–102. The gene discussed is SMPD1; the disease is Sepsis.