CERS2 and experimental autoimmune encephalomyelitis: Likewise, CerS2,6 modulates the migration of neutrophils, and CerS6 KO exacerbates the development of experimental autoimmune encephalomyelitis (EAE) with enhanced infiltration of neutrophils, while CERS2-deficient mice showed delayed development of EAE with decreased chemokine receptors (CCR1, CXCR1, and CXCR2)79,80, implying that the length of the carbon chain attached to the sphingoid base may differentially affect neutrophil function.