During the progression of murine MS, activated inflammatory monocytes (CD11b+CCR2+Ly6ChighLy6Glow) can migrate to and temporally reside in lymph nodes with expression of CD69, which retains inflammatory monocytes in the lymph node by internalization of S1PR1,5, and these monocytes prime and educate lymphocytes by supplying S1P and inflammatory cytokines for the development of TH17 and follicular helper T cells84. This evidence concerns the gene S1PR1 and myeloid sarcoma.