Moreover, ectopic overexpression of constitutively active Src (CA-SRC) significantly increased the mRNA and protein expression of AGT in BEAS-2B cells (Fig. 3f), and NNK-induced increases in AD colony formation (Fig. 3g) and formation of foci (Fig. 3g) were significantly suppressed by treatment with dasatinib. Here, AGT is linked to Alzheimer disease.