PAK1 and neoplasm: Moreover, tumor invasion, evaluated through matrigel-coated transwell inserts and spheroids’ invading area, was not impaired in parental not-invasive MCF7 and T47D (Supplementary Fig. 5b) while was strongly altered by PAK1 down-regulation in MCF7-FAR and T47D-FAR (Fig. 4e, f; Supplementay Fig. 5c, d).