One of the HRD samples (OESO_0047) did contain a somatic BRCA1 missense change, however, an HR-proficient tumour (OESO_0118) also contained a frameshift BRCA1 mutation (predicted pathogenic) and 3 other HR-proficient samples contained somatic BRAC1 or BRCA2 missense changes (see Supplementary Data 3 for all somatic coding mutations in the cohort). Here, BRCA1 is linked to neoplasm.