Accordingly, Cluster 2 (immune suppressed) and Cluster 4 (immune cold) showed a higher ratio of neutrophils/T-cells (CD4+ and CD8+) compared with Cluster 1 (immune hot) and Cluster 3 (immune moderate) tumours (Kruskal–Wallis, p = 0.00013) (Supplementary Fig. 23c). The gene discussed is CD4; the disease is neoplasm.