VHL and hereditary clear cell renal cell carcinoma: Top hits from the KrasG12D;Cas9 screen included genes known to be required for immune responses, such as Tapbl, encoding a component of the antigen-processing and presentation machinery; and Vhl (von-Hippel-Lindau), a tumor suppressor gene that enhances NK-cell activation in renal cell carcinoma (Fig. 3A)63.