All LV-sgRNA-Cre-OVA transduced lung cells also express and present the OVA antigen in the context of major histocompatibility complex class I (MHC-I) H2Kb molecules, which can be recognized by adoptively transferred cytotoxic OT-I CD8+ T cells and can ultimately lead to OT-I-mediated lysis of tumor cells. This evidence concerns the gene CD8A and neoplasm.