CD274 and neoplasm: For instance, in vivo genome-wide or epigenetic screens identified genes involved in IFNγ signaling and antigen presentation (PTPN2, ADAR1, APLNR); suppression of tumor-intrinsic immunogenicity (SETDB1); immune-editing of TME (ASAF1, COP1); and in direct stress response-induced regulation of PDL1 expression (EIF5)37–44.