The prominent role of IFNα/β, IFNγ and TNFα pathways in the induction of antigen processing and MHC-I-mediated antigen presentation on tumor cells prompted us to test H2Kb-OVA expression in CTRL and Adam2 O/E cells in response to IFNβ, IFNγ and TNFα treatment33,34,37,40,68–77. The gene discussed is TNF; the disease is neoplasm.