CD4 and infection: Notably, as we have previously demonstrated, it is possible to utilize adjuvants, specifically dmLT, to target intestinal tissues for residence by vaccine-specific CD4 T cells, but it is not at all clear whether adjuvants can impart a similar migratory phenotype on vaccine-specific B cells which would allow them to occupy local mucosal tissues where they may have the capacity to elicit infection neutralizing antibodies locally13.