Here, we found that LINC00839 promoted NPC proliferation and metastasis by mediating the recruitment of transcriptional factor TATA-box binding protein associated factor (TAF15) to the promoter region of amine oxidase copper-containing 1 (AOC1) and activating AOC1 transcription in trans. Furthermore, vir like m6A methyltransferase associated (VIRMA) and insulin-like growth factor 2 mRNA-binding proteins 1 (IGF2BP1) were found to promote the stability of LINC00839 in an m6A-dependent manner. The gene discussed is LINC00839; the disease is nasopharyngeal carcinoma.