The glial and neural cell activation markers, such as CSF neopterin, beta-2 microglobulin, sTREM2 (soluble ectodomain of triggering receptor expressed on myeloid cells 2), and GFAp (glial fibrillary acidic protein), were found to be significantly elevated in CSF studies of neurological COVID-19 patients. This evidence concerns the gene GFAP and COVID-19.