AKT1, PTGS2, MAPK1, TP53 and IL‐6 interacted with most of the potential pathways, including cancer pathways, the AGE‐RAGE signalling pathway, the FoxO signalling pathway, the HIF‐1 signalling pathway, the NF‐κB signalling pathway and lipids and atherosclerosis, which suggests that these genes might play a key role in the anti‐diabetic effects of fenugreek. This evidence concerns the gene TP53 and atherosclerosis.