To assess the impact of these transcriptional changes on the overall neuroinflammatory milieu, levels of the proinflammatory cytokines IFNγ, IL-10, IL-1β, IL-2, IL-5, IL-6, KC/GRO, and TNFα were measured in dissected hippocampus and overlying cortical regions from WT and AD mice (n = 6–13 per group). Here, IL5 is linked to Alzheimer disease.