However, in the hippocampus, a significant increase in soluble Aβ42 (Mann Whitney U Test; p = 0.036) and Aβ42/40 ratios (Student’s t-Test; p = 0.014) were detected in AD p38KO animals compared to AD p38+/+, suggesting that suppression of p38α may alter some aspects of amyloid deposition in this region (Fig 4A and 4B). Here, MAPK14 is linked to Alzheimer disease.