MAPK14 and early-onset autosomal dominant Alzheimer disease: In the context of Alzheimer’s disease (AD), amyloid beta (Aβ) contributes to p38-mediated release of proinflammatory cytokines both directly via increasing kinase activity and phosphorylation [4–9], as well as indirectly by promoting microglial activation and production of reactive oxygen species (ROS) [5, 7, 10–16].