Suppression of p38α in AD mice shifted the expression of 5 of these genes (Iifitm2, Csf2ra, Klf7, Cdc37l1, and N4bp2) to levels similar to those seen in WT animals, but enhanced the AD-associated changes in Rtp4 and Tmc7, suggesting differential effects of p38α inhibition across genes. Here, TMC7 is linked to Alzheimer disease.