We also identified similar changes in gene expression to what was reported in a study comparing irradiated (≤ 2 Gy) mice to patient’s with Alzheimer’s disease and identified significant modulation of genes for synaptic transmission, GTPase activity, MAPK signaling, Ephrin signaling, serine metabolism, kinesins, solute-carriers, GABA signaling, glutamate signaling, cytoskeletal reorganization, potassium channels, and ubiquitination [24, 97]. This evidence concerns the gene KCNA3 and early-onset autosomal dominant Alzheimer disease.