As mentioned above, in the context of certain infections iNKT cells require TCR signals from endogenous low affinity ligands to allow for their cytokine-dependent responses and in MAIT cells somewhat similar observations have been made in the context of SARS-CoV2 infection, where MAIT activation and responses are to some extent dependent on MR1 [102], even though the virus does provide any ligand. Here, MR1 is linked to infection.