Finally, while our main findings of TSPO VT associating with illness state and a correlation of the dorsal striatal TSPO VT with finger-tapping test performance reflect important associations between brain changes and clinical symptoms, they do not prove that elevations in TSPO VT (or gliosis) cause the symptoms of the disease state or cause poorer performance on the finger-tapping test. This evidence concerns the gene TSPO and Gliosis.