NEUROD6 and Parkinson disease: CR_SN and CR_LC from patients with PD were significantly decreased compared with those from non-PD patients in both NEX1 (CR_SN, 1.24 ± 0.03 for non-PD and 1.19 ± 0.04 for PD [p < 0.001]; CR_LC, 1.27 ± 0.03 for non-PD and 1.23 ± 0.03 for PD [p < 0.001]) and NEX1 + dDLR (CR_SN, 1.23 ± 0.03 for non-PD and 1.18 ± 0.04 for PD [p < 0.001]; CR_LC, 1.25 ± 0.03 for non-PD and 1.22 ± 0.03 for PD [p = 0.003]) (Fig. 5).