The definition of malnutrition had been difficult, due to the lack of a cohesive definition, a very important point of view on the argument has been outlined by Loftus et al., who specified that albumin serum level is only valid as marker of nutrition status, while at homeostasis, such orthopaedic elective patients undergoing TJA [8, 22]. This evidence concerns the gene ALB and nutritional deficiency disease.