CASP3 and neoplasm: The antineoplastic effects of As main reliance on the apoptosis of squamous cell carcinomas via producing reactive oxygen species (ROS) and activating JNK1/2 and caspase-3 (Eguchi et al. 2011; Potin et al. 2007), barium-mediated inhibition of arsenic-induced apoptosis can accelerate tumor progression in patients who exposure to both As and Ba (Yajima et al. 2012).