What is more, except for a significant positive correlation between LUSC and Ba, patients with EGFR mutations presented significantly negative correlations with Cd and Sr, and patients with TP53 mutations showed a significant positive correlation with Pb, suggesting that heavy metals may be regarded as supplementary characteristics for the sub-classification of NSCLC with different histological and molecular subtypes. Here, TP53 is linked to non-small cell lung carcinoma.