TP53 and cancer: More importantly, HST exerted greater proliferative inhibition on SW620 cells than on HCT-8 cells, evidenced by the lower IC50 value of HST on SW620, suggesting that HST might be a promising CRC drug candidate.p53 is usually expressed at a relatively low level or is functionally inactivated in patients with wtp53 through transcriptional or posttranscriptional regulation mechanisms, thereby resulting in loss of cancer suppression function [20].