PPARGC1A and metabolic dysfunction-associated steatotic liver disease: In line with this, scRNA-seq analysis of hepatic cells of mice fed with a SD or WD for 24 weeks (Remmerie et al., 2020) identified that expression levels of genes related to FFA uptake (Cd36), TG synthesis (Acsl1, Dgat1, and Dgat2), and GPx (Gpx1 and Gpx4) were increased, while β-oxidation (Ppargc1a and Cpt1a), GR (Gsr), and insulin signaling (Akt1) were decreased and Mogat1 was not changed in hepatocytes of NAFLD-induced mice (Figures 10C,D).