GPT and fatty liver disease: Moreover, 12 months of combinatorial oral administration of NAC (1.2 g per day) and metformin (850–1,500 mg per day) notably improved histological parameters, including hepatic steatosis, ballooning, and NAS score with decreased serum ALT levels in NASH patients (de Oliveira et al., 2008; Oliveira et al., 2019).