TYMS and Hand-foot syndrome: Recently, in the largest, so far, meta-analysis including more than 1,900 patients, TYMS 2R allele was associated with grade 3 HFS (OR 1.50), while TYMS 3′UTR 6bp ins/del was associated with overall toxicity (OR 1.21) and grade 3 HFS (OR 1.41) (Hamzic et al., 2020).