Similarly, dehydroabietic acid ameliorated high-fat diet-induced NAFLD by triggering Nrf2, elevating the levels of GSH, HO-1, and GPX4 for attenuating the accumulation of ROS and lipid peroxide MDA, subsequently suppressing hepatic ferroptosis (Gao et al., 2021). The gene discussed is GPX4; the disease is metabolic dysfunction-associated steatotic liver disease.