Evidently, aberrant cytokine signaling, such as the BAFF-TACI and CD40 signaling and high levels of NF-κBp65 phosphorylation are detected in autoreactive B cells of MRL/lpr mice and SLE patients (Dörner and Putterman, 2001; Stohl, 2003; Zhang et al., 2015). Here, CD40 is linked to systemic lupus erythematosus.