Previous studies have shown that some drugs, including curcumin, ibrutinib and losartan, can effectively inhibit rheumatoid arthritis, LN, systemic sclerosis and other autoimmune diseases by attenuating the NF-κB signaling to improve B cell function (Huang et al., 2013; Li et al., 2019; Wang et al., 2019; Einhaus et al., 2020). Here, NFKB1 is linked to lobular neoplasia.