In research on the effect of ectodermal-neural cortex 1 (ENC1) on radioresistance in breast cancer cells and showed that overexpression of ENC1 promoted intranuclear translocation of YAP/TAZ, enhanced the expression of GLI1, CTGF, and FGF1, and promoted the progression of breast cancer cells to bone and brain metastasis (76). The gene discussed is CCN2; the disease is breast cancer.