Interestingly, it has been shown that LAG3 and PD1, which are co-expressed by tumor antigens CD8+T cells, were damaged in the interferon -γ and tumor necrosis factor -α production, whereas the LAG3 and PD1 blocking restore the effect function of human ovarian tumor antigen T cells at higher levels than a single additive blocking LAG3 or PD1 alone. The gene discussed is TNF; the disease is neoplasm.