Cerebral Tregs-Foxp3 inhibits LPS-induced microglial reactivity and brain inflammation via IL-10, IL-35, CTLA4, and CD39 response pathways, suggesting immuno-surveillance and immunomodulatory roles of the gut-brain microglia Tregs-Foxp3 pathway in maintaining cerebral homeostasis (Xie et al., 2015). The gene discussed is FOXP3; the disease is brain inflammatory disease.