NECTIN2 and cancer: Nectin-2 is a immunoglobulin-like cell-to-cell adhesion protein that acts in a stimulatory or inhibitory manner Several studies on serum Nectin-2 have associated its overexpression with aggressiveness and metastasis in various cancers including colon, breast, esophageal and lung indicating its role as a prognostic and predictive biomarker in cancers (73–76).