CD8A and neoplasm: Some of the immune modulatory mechanisms associated with soluble forms include their binding to the treatment active site to hinder treatment efficacy, activation of immune suppressive molecules, inhibition of Interleukin-2 (IL-2) production/T cell activation, T cell apoptosis, upregulation of Tumor necrosis factor-α (TNF-α)/Interferon-gamma (IFN-γ) and early activation of CD8+ T cells leading either to tumor immune escape or control (10–13).