TIMD4 is a cell-surface glycoprotein and in cancers including renal cell carcinoma, diffuse large B-cell lymphoma, pancreatic cancer, and glioma, expression of TIMD4 has been associated with enhanced apoptosis, reduced clonogenic ability of cancer cells, and better survival (79–82). The gene discussed is TIMD4; the disease is hereditary clear cell renal cell carcinoma.