Moreover, a study on NSCLC patients observed that high Siglec-9 expression on infiltrating CD8+ T cells was associated with increased expression of PD-L1, co-expression of inhibitory receptors PD-1, TIM-3, Lag3, and reduced production of inflammatory cytokines leading to an exhausted T cell phenotype and poor survival in patients (50–52). This evidence concerns the gene CD274 and non-small cell lung carcinoma.