In addition to soluble T and NK markers, several studies have also reported on the role of tumor secreted antigens, such as Carcinoembryonic Antigen (CEA), Cytokeratin Fragment 19 (CYFRA21-1), and Carbohydrate Antigen 125 (CA-125), as biomarkers in some tumor types (20–22). The gene discussed is CEACAM5; the disease is neoplasm.