One single study, conducted on extracellular vesicle (EVs) proteins in 31 ICI-treated NSCLC patients, reported dynamic modulation of S100A8 with increased baseline associated with increased chemotaxis of myeloid cells (S100A8) while decreased expression (after treatment) was associated with inhibition of myeloid cell chemotaxis with induction of treatment response (109). This evidence concerns the gene S100A8 and non-small cell lung carcinoma.